Male fertility supplements: The science says it all
There is a lot of discussion these days about fertility solutions and the best way to get pregnant. Fruitful Way personalized fertility supplements were designed with science at the core. The Fruitful team of scientists and physicians conducted extensive research into the nutrients required to optimize fertility readiness. Consulting published scientific and medical literature, key opinion leaders in gynecology, andrology (male fertility) and embryology, the team carefully selected each of the formulation components. When choosing the nutrients, they paid particular attention to the most active forms of micronutrients – those that could most easily reach systemic circulation (bioavailable) to help maximize absorption and effect. For example, the ferrous fumarate form of iron was selected over other iron derivatives.
Personalized Fruitful Way supplement dosages are formulated to body mass index and to give the appropriate nutrient amounts according to lifestyle and infertility risk factors. The three-part Fruitful Way formulation – For Him, For Her and For the Couple view the couple as a single unit on their mission of trying to conceive.
Men: Half of the conception formula
Because physically, women bear the nine-month burden of carrying a baby, men have historically been left out of the picture. However, since men are responsible for half of the conception equation, it is essential that they are physiologically fit for their part of the pregnancy. This is why Fruitful Way has developed Fruitful for Him, the male fertility supplement formulation.
A word about oxidative stress and infertility
One of the major causes of defective sperm function is oxidative stress, which disrupts the integrity of sperm DNA and limits the fertilizing potential of these cells due to damage to proteins and lipids in the sperm fluid membrane. Oxidative damage affects the ability of sperm to swim and penetrate and fertilize eggs.
Oxidative stress is generated by chemicals called reactive oxygen species (ROS), and these are produced within cells or by environmental insults. Indeed, 25% of infertile men have high levels of reactive oxygen species in their semen. Since the sperm head is small, it is deficient in most mechanisms that protect from oxidative stress. Therefore, sperm fluid antioxidant capabilities play an important role in preserving sperm function. Studies have shown that men experience a significant improvement in semen characteristics after taking antioxidants.
Fruitful for Him: Male fertility vitamins and micronutrients
Have a look at the men’s scientific formulation and the components that have proven to contribute to men’s fertility.
Carnitine is an antioxidant that plays a role in sperm energy metabolism and provides the primary fuel for sperm motility (movement). When sperm passes from the testicles through the epididymis on their way to the vas deferens, they need motility to accelerate them on their journey. During this time, in normal biology, sperm have elevated L-carnitine levels. The role of carnitines is to enhance cellular energetics by helping free fatty acids within the “powerhouse of the cell” (the mitochondria). L-carnitine also helps restore the molecules that structure the mitochondrial membrane and protect cells by decreasing fatty acid oxidation.
In addition, carnitines protect sperm DNA and cell membranes from damage induced by reactive oxygen species, the chemically reactive molecules containing oxygen. Carnitines also help shield cells from programmed cell death (apoptosis).
Male patients with defective sperm motion have been shown to have reduced L-carnitine levels. Patients who took daily carnitine supplements showed improvements in both sperm motility and concentration. These improvements were correlated heavily with patients whose partners achieved pregnancy during treatment and follow-up.
The specific benefits of carnitine supplementation for male fertility
Randomized controlled trials demonstrated that a daily 2-gram dose of carnitine yielded the most significant improvement in men with low baseline motility. Morphology improved in as early as three months of treatment. In all studies that Fruitful Way evaluated, the positive effects of carnitine stabilized over a three-to-six month treatment period. This makes sense, since it takes three months to replace half the sperm supply in the testicles. Multiple studies have found that carnitine supplementation significantly improves both sperm activity and semen volume.
Carnitine can be found in a wide variety of foods, including red meat, dairy, nuts, grains and green vegetables.
There are many zinc benefits for men. Zinc is a “helper molecule" that assists in biochemical transformations for approximately 100 biological metallo-enzymes. It is a key element in important biological processes, such as converting DNA into genetic “blueprints” (transcription) and synthesizing protein. Zinc is not only an anti-oxidant, it also synergistically helps other anti-oxidants.
What the science shows
Abnormally low levels of zinc in seminal fluid are associated with infertility, while higher levels of zinc correlate significantly with increased sperm concentration and normal sperm morphology (shape). Fortunately, clinical studies have demonstrated that supplementing with zinc can improve sperm concentration, motility, and morphology, as well as fertilizing capacity, while reducing anti-sperm antibodies.
Male reproductive organ inflammation, caused most often by oxidative stress, is known to harm sperm production. Zinc for men functions as an anti-inflammatory agent. In pivotal clinical studies, male zinc treatment was directly associated with increased birth rates, reduced oxidative stress, decreased sperm apoptosis, and decreased sperm DNA fragmentation. The results held true for zinc taken alone or in combination with vitamins E and C.
Green Tea Extract
Epigallocatechin gallate (EGCG) is the most abundant and potent polyphenol antioxidant in green tea (Camellia sinensis). Green-tea-derived EGCG protects sperm-producing cells from environmentally induced damage and cell death. EGCG promotes normal male hormone balance (homeostasis) and its anti-inflammatory attributes help lower immune-cell infiltration into seminal fluid, preventing potential negative impact on sperm function.
Clinical research results: EGCG as a supplement for fertility
In normal male sperm, the introduction of low levels of EGCG supplements was associated with increased sperm motility, viability and processes that control cell survival. ECGC/estrogen receptors may be able to boost sperm’s fertilization potential by promoting motility, viability and enhancing energy expenditure.
Natural Vitamin E
Natural Vitamin E is an important antioxidant compound in the cell membrane. Experiments suggest that vitamin E may protect sperm from oxidative damage and loss of motility and enhance the sperm performance. Vitamin E is thought to both interrupt the cell-damage process in which free radicals "steal" electrons, and enhance antioxidants that scavenge free radicals.
The science behind the micronutrient for male fertility
Recent randomized control trials have reported that vitamin E is effective in treating infertile males with high ROS levels. Vitamin E treatment decreased concentrations of oxidative stress markers in sperm to normal levels, improving both motility and the probability of achieving pregnancy.
Increasing evidence suggests that the essential trace element selenium plays an important role in normal human growth, reproduction and male fertility. Selenium is key to the production of testosterone, the male sex hormone required for normal testicular development. The micronutrient is required for the formation and normal development of sperm, motility and function. It may protect sperm against oxidative DNA damage.
Studies have shown that selenium deficiencies lead to impaired motility, sperm mid-piece breakage and increased shape abnormalities, mostly affecting the sperm head. Patients with lower levels of selenium had lower sperm concentrations.
Science makes a strong case for combining selenium and vitamin E treatments since vitamin E works in synergy with selenium as an antioxidant. Clinical studies reported that combined treatment significantly increased motility and seminal fluid antioxidant activity and decreased oxidative degradation of lipids.
In several studies, infertile men who took selenium supplements experienced improvements in sperm quality and fertility.
The selenium content in food depends on the selenium content in the soil in which plants are grown. Due to over-farming or growth in soil poor in selenium, selenium food content is declining.
Getting the right amount of each micronutrient in male fertility vitamins
Each man’s recommended Fruitful for Him supplement dosage is calculated based on his fertility-potential assessment. This proprietary assessment, developed by the Fruitful medical, andrology and scientific team, combines comprehensive personal characteristics, lifestyle and environmental factors along with top-source scientific data and pregnancy success statistics to determine the supplement levels needed to boost fertility.
- Agarwal, A. & Sekhon, L. The role of antioxidant therapy in the treatment of male infertility. Human Fertility, 2010; 13(4): 217–225.
- Agarwal, A. Carnitine and male infertility. Reproductive Biomedicine, Vol. 8, No. 4, 2004; 376-384.
- Behne, D., Gebner, H., Wolters, G., & Brotherton, J. Selenium, rubidium and zinc in human semen and semen fractions. International Journal of Andrology, 1998; 11, 415–423.
- Burton, G. W., & Traber, M. G. Vitamin E: antioxidant activity, biokinetics, and bioavailability. Annual Review of Nutrition, 1990; 10, 357–382.
- De Amicis et al. Epigallocatechin gallate affects survival and metabolism of human sperm. Mol Nutr Food Res, 2012; 56(11):1655-64.
- de Lamirande, E., & Gagnon, C. Reactive oxygen species and human spermatozoa. I. Effects on the motility of intact spermatozoa and on sperm axonemes. Journal of Andrology, 1992; 13, 368–378.
- Hartoma TR, Nahoul K, Netter A. Zinc, plasma androgens and male sterility. The Lancet, 1977; 262(8048):1125-6.
- Jeulin, C., Lewin, LM. Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa. Hum Reprod Update,1996; 2(2):87-102.
- Kaedei, Y., Naito M., Naoi H., Sato, Y., Taniguchi, M, Tanihara, F, Kikuchi, K, Nagai, T, Otoi, T. Effects of (-)-epigallocatechin gallate on the motility and penetrability of frozen-thawed boar spermatozoa incubated in the fertilization medium. Reprod Domest Anim, 2012; 47(6):880-6.
- Kesker-Ammar, L., Feki Chacroun, N., Rebai, T., Sahnoun, Z., Ghozzi, H., Hammami, S., et al. (2003). Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Archives of Andrology, 2003; 49, 83–94.
- Lenzi, A., Lombardo, F., Sgrò, P., Salacone, P., Caponnecchia, L., & Dondero, F. Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial. Fertility and Sterility, 2003; 79, 292–300.
- Lenzi, A., Sgrò, P., Salacone, P., Paoli, D., Gilio, B., Lombardo, F., et al. A placebo-controlled double-blind randomized trial of the use of combined L-carnitine and L-acetylcarnitine treatment in men with asthenozoospermia. Fertility and Sterility, 2004; 81, 1578–1584
- Noack-Fille, G., De Beer, C., & Sweibert, H. Cadmium, lead, selenium, and zinc in semen of occupationally unexposed men. Andrologia, 1993; 25, 7–12.
- Omu, AE, Al-Azemi, MK, Kehinde, EO, et al. Indications of the mechanisms involved in improved sperm parameters by zinc therapy. Med Princ Pract, 2008; 17(2):108-16.
- Omu, AE, Dashti, H, Al-Othman, S. Treatment of asthenozoospermia with zinc sulphate: andrological, immunological and obstetric outcome. Eur J Obstet Gynecol Reprod Biol, 1998; (2):179-84.
- Palamanda, J. R., & Kehrer, J. R. Involvement of vitamin E and protein thiols in the inhibition of microsomal lipid peroxidation by glutathione. Lipids, 1993; 28, 427–43l.
- Ross, C., Morriss, A., Khairy, M., Khalaf, Y., Braude, P., Coomarasamy, A., et al. A systematic review of the effect of oral antioxidants on male infertility. Reproductive Biomedicine Online, 2010; 20, 711–723.
- Suleiman, S. A., Ali, M. E., Zaki, Z. M., el-Malik, E. M., & Nasr, M. A. Lipid peroxidation and human sperm motility: protective role of vitamin E. Journal of Andrology, 1996; 17, 530–537.
- Tikkiwal, M, Ajmera, RL, Mathur, NK. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol, 1987; 31(1):30-4.
- Ursini, F., Heim, S., Kiess, M., Maiorino, M., Roveri, A., Wissing, J., et al. Dual function of the selenoprotein PHGPx during sperm maturation. Science, 1999; 285, 1393–1396.
- Vezina, D., Mauffette, F., Roberts, K. D., & Bleau, G. Selenium-vitamin E supplementation in infertile men. Biological Trace Element Research, 1996; 53, 65–83.
- Vicari, E., & Calogero, A. E. Effects of treatment with carnitines in infertile patients with prostato-vesiculo-epididymitis. Human Reproduction, 2001; 16, 2338–2342.
- Wallace, E., Calvin, H. I., Ploetz, K., & Cooper, G. W. Functional and developmental studies on the role of selenium in spermatogenesis. In Combs, G. F. Jr., Spallholz, J. E., Levander, O. A., & Oldfield, J. E., (Eds), Selenium in biology and medicine, part A. New York: AVI, 1987; pp. 181–196.
- Zago, MP, & Oteiza, PI. The antioxidant properties of zinc: interactions with iron and antioxidants. Free Radic Biol Med, 2001; 1531(2):266-74.